Medical Equipment & Systems

SuperSaturated Oxygen Therapy

TherOx SSO₂ System

Temperature Management

Thermogard XP

TherOx SSO₂ System

Hyperoxemic Reperfusion Therapy to Minimise Infarct Size

The TherOx SSO₂ System is the first FDA-approved, catheter-based treatment engineered to deliver SuperSaturated Oxygen (SSO₂) Therapy immediately after primary PCI for anterior STEMI. By perfusing the jeopardised myocardium with autologous blood superoxygenated to hyperbaric levels, the system restores microvascular flow, limits tissue damage, and helps preserve long-term cardiac function.

Targeted Hyperoxemic Therapy

One-time 60-minute infusion: performed directly after successful LAD stenting, with no impact on door-to-balloon time.
High oxygen delivery: delivers blood with a pO₂ ≈ 1 000 mmHg—roughly 7-to-10 × normal arterial oxygen tension—to optimise oxygen diffusion into ischemic tissue.
5 F over-the-wire SSO₂ Catheter: positions in the left main coronary ostium via the femoral access site to bathe the infarct zone.

Closed-Loop, Three-Component System

DownStream™ Console: mobile unit that automates set-up, mixing, and real-time therapy control.
Disposable Cartridge: creates superoxygenated saline from standard hospital oxygen and saline, then blends it continuously with the patient's arterial blood.
SSO₂ Catheter: delivers the finished hyperoxemic blood to the coronary circulation. Total device set-up time is under five minutes.

Proven Clinical Benefit

Significant infarct size reduction: randomised trials show a 26 % median infarct-size reduction compared with PCI alone in LAD STEMI patients.
Improved long-term outcomes: lower one-year rates of death or new-onset heart failure have been observed when SSO₂ Therapy is added to standard care.

Technical Specifications

Components:	Console, single-use Cartridge, 5 F SSO₂ Catheter
Indication:	Post-PCI infusion for anterior AMI (LAD) completed ≤ 6 h from symptom onset
Infusion Duration:	60 min continuous
Oxygen Tension:	~1 000 mmHg pO₂ in treated blood
Set-up Time:	< 5 min device preparation
Catheter Size:	5 F O.D., over-the-wire

The TherOx SSO₂ System empowers interventional teams to go beyond vessel patency, delivering hyperoxemic blood where it matters most to protect vulnerable myocardium and improve long-term outcomes for heart-attack patients.